News




Home News Technical articles Application of sterilizing filtration products in injection production process

Application of sterilizing filtration products in injection production process

2024-03-12 Eternalwater

Injections refer to raw materials or sterile preparations made with appropriate excipients for injection into the body. Injections are divided into large-volume injections (large infusion or LVP), small-volume injections (small injections or SVP) and powder injections according to their production technology characteristics and production processes. Among them: large-volume injection (LVP) is commonly known as large infusion, which refers to a volume of ≥ 50ml liquid sterilization preparation that is directly injected into the vein; small volume injection (SVP), commonly known as water injection, configures the drug into a solution (aqueous or non-aqueous), suspension or emulsion, and puts it into an ampoule or multi-dose container. The prepared sterile preparation has a general capacity of ≤20mL.




membrane pleated filter cartridge


Due to the particularity of the administration site of this type of preparation, its quality requirements and safety risks are very high. The sterility of the final product must be ensured, that is, the drug cannot contain bacteria and other microorganisms. This is also an important guarantee to ensure patient safety. Therefore, sterile filtration is particularly important in the entire process.

Filtration is widely used in different process stages of large and small volume injections. It mainly includes decarbonization filtration, particle removal and pre-filtration to reduce microbial load, gas sterilization filtration, redundant filtration and sterilization filtration of end products. etc. The main filtering sites are:
pleated filter cartridge factory
1. Decarbonization filtration: remove activated carbon particles and colloidal impurities, extending the service life of downstream filters
2. Pre-filtration (particle removal): further remove activated carbon particles and colloidal impurities, extending the service life of downstream filters
3. Pre-filtration (reduce microbial load): Reduce microbial load and extend the service life of downstream sterilization filter elements
4. Redundant filtration: remove bacteria and microorganisms in the filtrate
5. Terminal sterilization filtration: remove bacteria and microorganisms in the terminal filtrate
6. Respirator: balance tank pressure and prevent pollution

Common large and small volume injection production processes



Last News



About 202410th China Veterinary Drug Exhibition (CCUM) - Exhibition invitation
About 202410th China Veterinary Drug Exhibition (CCUM) - Exhibition invitation
The China Veterinary Medicine Exhibition has been successfully held for nine sessions and has become an annual grand event for the Chinese veterinary medicine industry. It is a communication and excha
Read more 2024-06-07
Exhibition invitation About CPHI&PMEC China 2024 - Eternalwater
Exhibition invitation About CPHI&PMEC China 2024 - Eternalwater
From June 19 to 21, 2024, the "22nd World Pharmaceutical Raw Materials China Exhibition (CPHI China 2024)" will join hands with the "17th World Pharmaceutical Machinery
Read more 2024-05-30
Wonderful review CIBF 2024 - Eternalwater
Wonderful review CIBF 2024 - Eternalwater
The 16th Chongqing International Battery Technology Exchange Conference / Exhibition Constant water filtration with a series of products appeared in N7 hall T243 booth, with a number of domestic and f
Read more 2024-04-30
Exhibition invitation 16th China International Battery Fair
Exhibition invitation 16th China International Battery Fair
The 16th Chongqing International Battery Technology Exchange/Exhibition (CIBF2024) with the theme of "Linking the World, Empowering Green, and Driving the Future" will be held grandly at the Chongqing
Read more 2024-04-22
Biochina 2024 was successfully held in the Suzhou International Expo Center from 14 -16 March
Biochina 2024 was successfully held in the Suzhou International Expo Center from 14 -16 March
As a leading filtration solution provider for bio-pharmaseutical industry, Hangzhou Eternalwater Filtration took a series of products to the E3 Raw Materials/Reagents/Consumables Hall - Booth SE073
Read more 2024-03-20
Eternalwater Filtration invites you to participate in BTF2024
Eternalwater Filtration invites you to participate in BTF2024
As the flagship event of the new energy lithium battery industry, BTF Shanghai International New Energy Lithium Battery Technology Exhibition has been deeply involved in the lithium battery industry
Read more 2024-03-06
Read more
  • Subscribe for Join Us!



  • Join us and get detail information,technical parameter and new products etc.
CopyRight © Hangzhou Eternalwater Filtration Equipment Co., Ltd. 2002-2024